Methotrexate HS Code Trade Classification — 43 Codes, $35.0M Trade

Q: How much Methotrexate is exported under HS code 30049042?

Under HS code 30049042, India exports $33.4M worth of Methotrexate, representing 95.4% of total Methotrexate trade. This involves 2,487 shipments from 310 Indian exporters to 725 buyers in 292 countries.

Q: Which countries import the most Methotrexate from India?

The top importing countries for Methotrexate from India are United Kingdom, United States, Mexico. The leading importer United Kingdom accounts for $10.3M in trade value. In total, Methotrexate is exported to buyers across multiple countries under 43 HS code classifications.

Q: Who are the top Methotrexate exporters from India?

The leading Methotrexate exporters from India include CIPLA LIMITED ($16.8M), EUGIA PHARMA SPECIALITIES LIMITED ($2.3M), CIPLA LIMITED ($1.6M). These suppliers export across multiple HS code classifications with a combined trade value of $35.0M.

TransData Nexus

Methotrexate

India Pharmaceutical Trade Intelligence

$34.9M353 Suppliers148 CountriesHS 30049042

ExportsIndia → UNITED KINGDOM29.6%India → UNITED STATES16.3%

ImportsUNITED STATES → India$53.1K GERMANY → India$5.5K

#1 Supplier: CIPLA LIMITED #1 Buyer: ALLOGA UK

Methotrexate HS Codes (2026) — 43 Classifications, $35.0M Trade | TransData Nexus | TransData Nexus

Methotrexate HS Code Analysis (2026)

India exports Methotrexate under 43 distinct HS code classifications, representing a total trade value of $35.0M across 3,841 shipments. The dominant classification is HS 30049042 (Anti-diarrhoeal preparations, put up for retail sale), accounting for 95.4% of all Methotrexate trade at $33.4M. HS 30049099 (Other medicaments, put up in measured doses or for retail sale) follows at 2.3% ($819.0K). The top 5 HS codes together account for 99.5% of total Methotrexate trade from India. The average transaction value is $9108. Key importing markets include United Kingdom, United States, Mexico. Leading exporters include CIPLA LIMITED and EUGIA PHARMA SPECIALITIES LIMITED. Data sourced from Indian Customs (DGFT) shipping bill records.

Source:

Methotrexate HS Code Analysis — 43 classifications, $35.0M trade value, top HS codes breakdown and distribution — Methotrexate HS code analysis — 43 classifications · $35.0M trade value · 3,841 shipmentsTransData Nexus · Indian Customs Data

Top Methotrexate HS Code Classifications

Ranked by trade value from Indian Customs (DGFT) data

Rank	HS Code	Trade Value	Share	Transactions	Avg Price	Suppliers	Countries
#1	30049042	$33.4M	95.4%	2,487	$750.03	310	292
#2	30049099	$819.0K	2.3%

HS 30049042

Anti-diarrhoeal preparations, put up for retail sale · 95.4% of Methotrexate trade

$33.4M

Trade Value

95.4%

Market Share

2,487

Transactions

$750.03

Avg Unit Price

Suppliers: 310Buyers: 725Countries: 292

Common Product Descriptions:

LEETREXATE 2.5 MG TAB (METHOTREXATE TAB

FOLITRAX TAB (METHOTREXATE 7.5MG)

METHOTREX 2.5 MG TAB (METHOTREXATE TABLE

HS 30049099

Other medicaments, put up in measured doses or for retail sale · 2.3% of Methotrexate trade

$819.0K

Trade Value

2.3%

Market Share

736

Transactions

$488.90

Avg Unit Price

Suppliers: 205Buyers: 250Countries: 140

Common Product Descriptions:

METHOCEL 50MG INJ (METHOTREXATE)

METREX 2.5MG TABLET (METHOTREXATE 2.5MG

METHONID 10MG TAB. METHOTREXATE TABLETS

HS 30049049

Other gastrointestinal preparations (retail) · 1.2% of Methotrexate trade

$433.8K

Trade Value

1.2%

Market Share

338

Transactions

$2.45

Avg Unit Price

Suppliers: 97Buyers: 133Countries: 113

Common Product Descriptions:

Methotrexate Injection 50mg (ZUVTTREX 50

METHOTREXATE IP

ONCOTREX 7.5MG (METHOTREXATE) SIZE-10 TA

HS 30049099

Other medicaments of mixed or unmixed products (retail) · 0.3% of Methotrexate trade

$98.0K

Trade Value

0.3%

Market Share

Transactions

$2.11

Avg Unit Price

Suppliers: 10Buyers: 8Countries: 12

Common Product Descriptions:

METHO-ML 1000MG(METHOTREXATE 1000MG/40ML INJ)

PHARMACEUTICALS PRODUCTS METHOTREXATE 80MG TABLET ...

IMUNOTRAX 15MG TAB. METHOTREXATE TABLETSIP 15MG ( ...

HS 30042099

Medicaments containing antibiotics (retail) · 0.2% of Methotrexate trade

$55.5K

Trade Value

0.2%

Market Share

Transactions

$1.33

Avg Unit Price

Suppliers: 6Buyers: 9Countries: 9

Common Product Descriptions:

H M METHOTREXATE INJECTION 25MG ML N10 CLEAR GLASS...

HARMLESS MEDICINES METHOTREXATE TABLETS

FOLITRAX 10MG 10S METHOTREXATE TABLETS

HS 30049089

Other anti-neoplastic/immunomodulating agents (retail) · 0.2% of Methotrexate trade

$53.9K

Trade Value

0.2%

Market Share

Transactions

$0.50

Avg Unit Price

Suppliers: 2Buyers: 3Countries: 2

Common Product Descriptions:

EMTHEX 50 INJECTION (METHOTREXATE SOLUTI

PHARMA DRUGS & MEDI: METHOTREXATE INJ,25

HS 30049042

Other medicaments of mixed or unmixed products (retail) · 0.1% of Methotrexate trade

$40.8K

Trade Value

0.1%

Market Share

Transactions

$1.41

Avg Unit Price

Suppliers: 22Buyers: 21Countries: 21

Common Product Descriptions:

PHARMA DRUGS AND MEDICINE-METHOTREXATE W-P25MG/ML,...

PHARMA DRUGS & MEDI METHOTREXATE INJ 25MG/ML 2ML (...

HS 30049092

Anti-asthma preparations, put up for retail sale · 0.1% of Methotrexate trade

$32.6K

Trade Value

0.1%

Market Share

Transactions

$3.16

Avg Unit Price

Suppliers: 8Buyers: 11Countries: 10

Common Product Descriptions:

Methofast 500(Methotrexate Injection Ip

Methofast 500MG(Methotrexate Injection 5

Methofast 500MG-Methotrexate Inj

HS 30049067

Other medicaments of mixed or unmixed products (retail) · 0.0% of Methotrexate trade

$10.7K

Trade Value

0.0%

Market Share

Transactions

$1.31

Avg Unit Price

Suppliers: 1Buyers: 1Countries: 1

Common Product Descriptions:

H.M.METHOTREXATE INJECTION 25MG/ML,N10.C

#10

HS 30049043

Laxative preparations, put up for retail sale · 0.0% of Methotrexate trade

$8.1K

Trade Value

0.0%

Market Share

Transactions

$3.47

Avg Unit Price

Suppliers: 2Buyers: 2Countries: 2

Common Product Descriptions:

PHARMA: METHOTREXATE INJ USP 500 MG TRE

REDITREX 2.5 MG TAB (EACH UNCOATED TAB CONTAINS ME...

#11

HS 30049047

Other medicaments of mixed or unmixed products (retail) · 0.0% of Methotrexate trade

$5.6K

Trade Value

0.0%

Market Share

Transactions

$2.83

Avg Unit Price

Suppliers: 4Buyers: 5Countries: 5

Common Product Descriptions:

TREXOL 1 G METHOTREXATE INJECTION USP 10

METHOTREXATE TABLETS USP 2.5MG

HARMLESS MEDICINE FOR HUMAN CONSUMPTIONMETHOTREXAT...

#12

HS 30049041

Antacid preparations, put up for retail sale · 0.0% of Methotrexate trade

$5.2K

Trade Value

0.0%

Market Share

Transactions

$2.68

Avg Unit Price

Suppliers: 9Buyers: 10Countries: 12

Common Product Descriptions:

METHOTREXATE TABLETS IP 2.5MG

Methotrexate 1g Injection

MEDICINES FOR CONSUMPTION AND THE DESCRIPTION OF T...

#13

HS 30067000

Gel preparations for human/veterinary medicine as lubricant · 0.0% of Methotrexate trade

$5.1K

Trade Value

0.0%

Market Share

Transactions

$1.00

Avg Unit Price

Suppliers: 1Buyers: 1Countries: 1

Common Product Descriptions:

TREXGLO 2.5 MG (3X10'S) (METHOTREXATE T

#14

HS 30049095

Dermatological preparations, put up for retail sale · 0.0% of Methotrexate trade

$4.7K

Trade Value

0.0%

Market Share

Transactions

$2.07

Avg Unit Price

Suppliers: 3Buyers: 3Countries: 3

Common Product Descriptions:

MTREXATE 50MG INJ.METHOTREXATE INJ. I.P.VAIL B.NOI...

HARMLESS MEDI FOR HUMAN METHOTREXATE INJECTION IP ...

INDIAN ORIGIN HARMLESS PHARMA MEDICINES MTREXATE 5...

#15

HS 30033900

Other medicaments containing hormones (not put up for retail) · 0.0% of Methotrexate trade

$3.2K

Trade Value

0.0%

Market Share

Transactions

$6.36

Avg Unit Price

Suppliers: 1Buyers: 1Countries: 1

Common Product Descriptions:

METHOTREXATE INJ USP 25MG/ML 40 VIAL LOT:P2205557L...

#16

HS 30049039

Other anti-infective/anti-parasitic medicaments (retail) · 0.0% of Methotrexate trade

$2.8K

Trade Value

0.0%

Market Share

Transactions

$0.63

Avg Unit Price

Suppliers: 6Buyers: 6Countries: 5

Common Product Descriptions:

METHOTREXATE TABLE IP 2.5 MG - T212457

METHOTREXATE TABLET IP 2.5 MG - BATCH NO

BIOTREXATE 500MG. INJ. (METHOTREXATE )NOS

#17

HS 30049045

Other medicaments of mixed or unmixed products (retail) · 0.0% of Methotrexate trade

$1.6K

Trade Value

0.0%

Market Share

Transactions

$1.03

Avg Unit Price

Suppliers: 2Buyers: 2Countries: 2

Common Product Descriptions:

METHOTREXATE 500MG/20ML (7802227)

METHOTREXATE 5MG/2ML (7802241)

PLACEBO FOR METHOTREXATE 2.5MG/ML SOLUTI

#18

HS 30049044

Other medicaments of mixed or unmixed products (retail) · 0.0% of Methotrexate trade

$1.5K

Trade Value

0.0%

Market Share

Transactions

$1.45

Avg Unit Price

Suppliers: 2Buyers: 3Countries: 4

Common Product Descriptions:

METHOTREXATE 50MG INJ,PACK-1 vial (ZUVIT

METHOTREXATE 2 5 MG TABLETS PACKING 10X10

METHOTREXATE 2.5MG TABLETS(PACKING : 10X10) (PHARM...

#19

HS 30049094

Ophthalmic preparations, put up for retail sale · 0.0% of Methotrexate trade

$1.3K

Trade Value

0.0%

Market Share

Transactions

$1.59

Avg Unit Price

Suppliers: 2Buyers: 2Countries: 2

Common Product Descriptions:

BIOTREXATE 500 MG(METHOTREXATE INJECTION

METHOTREXATE - TABLETS - 10MG - FOLITRAXBATCH NO: ...

METHOTREXATE - TABLETS - 7.5MG - FOLITRAX BATCH N...

#20

HS 30049079

Other CNS acting medicaments (retail) · 0.0% of Methotrexate trade

$1.2K

Trade Value

0.0%

Market Share

Transactions

$2.40

Avg Unit Price

Suppliers: 2Buyers: 2Countries: 2

Common Product Descriptions:

BIOTREXATE 50MG/METHOTREXATE INJECTION

UNITREXATE 500 (METHOTREXATE INJECTION I

Where Methotrexate is Exported — Geographic HS Code Analysis

Import destinations for Methotrexate from India, by trade value

India exports Methotrexate to 10+ countries under 43 HS code classifications. The largest import destination is United Kingdom ($10.3M), followed by United States ($5.7M) and Mexico ($2.9M). These markets collectively account for the majority of India's Methotrexate pharmaceutical exports.

Rank	Country	Trade Value	Market Share
#1	United Kingdom	$10.3M	29.5%
#2	United States	$5.7M	16.3%
#3	Mexico	$2.9M	8.4%
#4	Saudi Arabia	$1.8M	5.2%
#5	Turkey	$1.7M	4.9%
#6	Sri Lanka	$1.1M	3.0%
#7	Canada	$1.0M	3.0%
#8	Thailand	$857.9K	2.5%
#9	Australia	$813.7K	2.3%
#10	Netherlands	$692.6K	2.0%

Pharmaceutical buyers in these markets import Methotrexate primarily under HS code 30049042 (Anti-diarrhoeal preparations, put up for retail sale). Import duties, regulatory requirements, and product registration vary by destination country. Contact TransData Nexus for country-specific import intelligence.

Understanding Methotrexate HS Codes

The Harmonized System (HS) is an internationally standardized system of names and numbers to classify traded products. Developed by the World Customs Organization (WCO), it is used by over 200 countries for customs tariffs, trade statistics, and regulatory compliance. Each HS code is a 6-digit number (extended to 8 digits in India's Customs Tariff Schedule) that precisely identifies a product category.

How Methotrexate HS Codes Work

Methotrexate falls under Chapter 30 (Pharmaceutical Products) of the Harmonized System. The 43 codes used for Methotrexate exports span multiple headings:

Heading 3003 — Medicaments not put up in measured doses or for retail sale (bulk APIs, intermediates)
Heading 3004 — Medicaments put up in measured doses or for retail sale (finished formulations)
Heading 3005 — Wadding, gauze, bandages for medical use
Heading 3006 — Pharmaceutical goods (sutures, reagents, dental cements)

The most significant distinction for Methotrexate is between HS 3003 (bulk/unmeasured) and HS 3004 (retail-ready). HS 3004 codes account for the majority of Methotrexate trade (including the dominant code 30049042 at 95.4%). The 8-digit Indian Customs Tariff code further specifies the therapeutic class — for example, HS 30049042 refers to "Anti-diarrhoeal preparations, put up for retail sale".

Regulatory & Compliance — Methotrexate Export Classification

Correct HS code classification is critical for Methotrexate exports from India. Misclassification can result in customs delays, incorrect duty assessment, and regulatory penalties. Key compliance considerations for pharmaceutical stakeholders:

Import Duty Classification

Methotrexate import duties vary significantly by HS code and destination country. HS 3004 (finished formulations) typically attracts different duty rates than HS 3003 (bulk APIs). Many developing countries offer preferential rates for essential medicines including Methotrexate.

DGFT & Indian Customs Requirements

Indian exporters must declare the correct 8-digit ITC-HS code on shipping bills filed with the Directorate General of Foreign Trade (DGFT). Methotrexate exports require Drug Controller General of India (DCGI) approval and must comply with Drug & Cosmetics Act regulations.

WHO Prequalification

For international procurement (UNICEF, Global Fund), Methotrexate products must meet WHO Prequalification standards. WHO PQ status affects which HS codes are eligible for preferential procurement pricing and duty exemptions in recipient countries.

Country-Specific Registration

Each destination country requires product registration before import. Key markets like United Kingdom and United States have specific pharmaceutical regulatory bodies that must approve the product before customs clearance.

Related Immunosuppressants — Products Sharing Similar HS Codes

Other products in the Immunosuppressants therapeutic category that may share HS code classifications with Methotrexate

cyclosporine tacrolimus sirolimus

Tariff Schedule — Top Markets

TransData Nexus Methotrexate HS code trade compliance intelligence

1Tariff Schedule — Top Markets

Methotrexate, classified under HS code 30049042, is subject to varying Most Favored Nation (MFN) tariff rates and preferential treatments across key importing countries.

United Kingdom and European Union: Both the UK and EU apply an MFN tariff rate of 0% for products under HS code 300490, encompassing Methotrexate. This indicates duty-free entry for such pharmaceutical products.

United States: The U.S. Harmonized Tariff Schedule (HTS) lists HS code 300490 as duty-free under the MFN rate. Additionally, the U.S. has Free Trade Agreements (FTAs) with several countries, potentially offering preferential rates; however, specific details for Methotrexate under these agreements should be verified through the U.S. International Trade Commission's HTS database.

Mexico: As a member of the United States-Mexico-Canada Agreement (USMCA), Mexico offers preferential tariff rates for pharmaceutical products originating from member countries. The specific rate for HS code 30049042 should be confirmed through Mexico's national customs authority.

Saudi Arabia: Saudi Arabia's MFN tariff rate for pharmaceutical products under HS code 300490 is 0%, indicating duty-free importation. No specific FTA with India affects this rate.

Classification Disputes & Misclassification Risks

TransData Nexus Methotrexate HS code trade compliance intelligence

1Classification Disputes & Misclassification Risks

Methotrexate is predominantly classified under HS code 30049042, accounting for 95.4% of trade transactions according to TransData Nexus data. This code pertains to "Other medicaments containing alkaloids or derivatives thereof, not elsewhere specified."

Classification disputes often arise between HS codes 3003 and 3004:

HS Code 3003: Covers "Medicaments consisting of two or more constituents mixed together for therapeutic or prophylactic uses, not put up in measured doses or in forms or packings for retail sale."

HS Code 3004: Encompasses "Medicaments consisting of mixed or unmixed products for therapeutic or prophylactic uses, put up in measured doses or in forms or packings for retail sale."

The primary distinction lies in the packaging and dosing:

Bulk Form (HS 3003): Methotrexate in bulk form, not packaged for retail sale or in measured doses, should be classified under HS code 3003.

Retail Form (HS 3004): Methotrexate prepared in measured doses or retail packaging falls under HS code 3004.

Common misclassification errors include:

Pharmacopoeia & Quality Standards

TransData Nexus Methotrexate HS code trade compliance intelligence

1Pharmacopoeia & Quality Standards

Methotrexate is recognized in several major pharmacopoeias, including the United States Pharmacopeia (USP), British Pharmacopoeia (BP), European Pharmacopoeia (EP), and Indian Pharmacopoeia (IP). These monographs establish stringent quality standards to ensure the safety and efficacy of Methotrexate formulations.

Purity and Assay Requirements: The USP monograph specifies that Methotrexate should have a purity of ≥99.0% as determined by High-Performance Liquid Chromatography (HPLC). Assay tests confirm the drug's potency, typically requiring the content to be within 99.0% to 101.0% of the labeled amount.

Dissolution Testing: Dissolution tests assess the rate at which Methotrexate releases its active ingredient in the body, ensuring consistent bioavailability. These tests are crucial for oral dosage forms and are conducted following protocols outlined in the respective pharmacopoeias.

Stability Testing: Stability studies are conducted per the International Council for Harmonisation (ICH) guidelines, considering different climatic zones. These tests evaluate the drug's shelf life and storage conditions, ensuring it maintains its efficacy and safety over time.

Adherence to these pharmacopoeial standards is essential for regulatory approval and market acceptance of Methotrexate products. Manufacturers must ensure compliance with these quality requirements to meet global health and safety standards.

Frequently Asked Questions — Methotrexate HS Codes

Common questions about Methotrexate trade classification, answered with data from Indian Customs records.

What is the HS code for Methotrexate exports from India?

The most commonly used HS code for Methotrexate exports from India is 30049042 (Anti-diarrhoeal preparations, put up for retail sale), which accounts for 95.4% of all Methotrexate trade valued at $33.4M. In total, India exports Methotrexate under 43 distinct HS code classifications.

How many HS codes are used for Methotrexate trade?

Methotrexate is exported from India under 43 different HS code classifications, covering a total trade value of $35.0M across 3,841 shipments. The top 5 HS codes account for 99.5% of total trade.

What is HS code 30049042?

HS code 30049042 refers to "Anti-diarrhoeal preparations, put up for retail sale" under Chapter 30 (Pharmaceutical Products) of the Harmonized System. For Methotrexate, this code covers $33.4M in trade value with 2,487 transactions, 310 suppliers, and 725 buyers across 292 countries. The average unit price under this code is $750.03.

What is the difference between HS 30049042 and 30049099 for Methotrexate?

HS 30049042 (Anti-diarrhoeal preparations, put up for retail sale) accounts for 95.4% of Methotrexate trade ($33.4M) with an average unit price of $750.03, while HS 30049099 (Other medicaments, put up in measured doses or for retail sale) covers 2.3% ($819.0K) at $488.90 per unit. HS 30049042 involves 310 suppliers and 725 buyers, compared to 205 suppliers and 250 buyers for HS 30049099.

Official References & Regulatory Resources

HS code classifications follow the WCO Harmonized System. Verify tariff rates with your national customs authority.

Research Methodology & Data Transparency

Suresh Sormare

Verified Author

Pharmaceutical Export-Import Analyst & Trade Intelligence Expert

Suresh Sormare is a pharmaceutical export-import analyst with deep expertise in Indian Customs (DGFT) data, HS code classification, and global pharmaceutical supply chains. His analysis covers 10M+ shipment records across 150+ countries and is used by manufacturers, procurement agencies, and trade consultants worldwide. Suresh specializes in identifying verified suppliers and buyers from customs records, mapping bilateral pharmaceutical trade corridors, analyzing tariff structures and regulatory frameworks across 170+ destination markets, and benchmarking competitive positioning for finished pharmaceutical formulations. His methodology combines granular customs transaction data with regulatory intelligence from FDA, EMA, WHO, CDSCO, and 40+ national drug authorities to deliver actionable trade insights for the pharmaceutical formulations sector.

linkedin.com/in/sureshsormare

Primary Data Source

All trade data is sourced from Indian Customs (DGFT) official shipping bill records — the authoritative government database for India's pharmaceutical trade. Each verified record contains exporter name, consignee (buyer) name, detailed product description, quantity, declared FOB value (USD), port of loading, destination country, and shipment date.

Methotrexate

Methotrexate

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All Methotrexate HS Code Classifications

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Where Methotrexate is Exported — Geographic HS Code Analysis

Understanding Methotrexate HS Codes

How Methotrexate HS Codes Work

Regulatory & Compliance — Methotrexate Export Classification

Import Duty Classification

DGFT & Indian Customs Requirements

WHO Prequalification

Country-Specific Registration

Related Immunosuppressants — Products Sharing Similar HS Codes

Tariff Schedule — Top Markets

1Tariff Schedule — Top Markets

Classification Disputes & Misclassification Risks

1Classification Disputes & Misclassification Risks

Pharmacopoeia & Quality Standards

1Pharmacopoeia & Quality Standards

Frequently Asked Questions — Methotrexate HS Codes

What is the HS code for Methotrexate exports from India?

How many HS codes are used for Methotrexate trade?

What is HS code 30049042?

What is the difference between HS 30049042 and 30049099 for Methotrexate?

Official References & Regulatory Resources

Research Methodology & Data Transparency

Suresh Sormare

Primary Data Source

How much Methotrexate is exported under HS code 30049042?

Which countries import the most Methotrexate from India?

Who are the top Methotrexate exporters from India?

Analysis Methodology