Methotrexate Export Market Intelligence: India's 353 Suppliers Shipping to 148 Countries — TransData Nexus 2026

Q: Who are the top methotrexate exporters from India?

The top methotrexate exporters from India are: 1. CIPLA LIMITED — $18.4M (52.8% market share); 2. EUGIA PHARMA SPECIALITIES LIMITED — $3.0M (8.6% market share); 3. INTAS PHARMACEUTICALS LIMITED — $1.5M (4.4% market share); 4. ZYDUS LIFESCIENCES LIMITED — $1.3M (3.7% market share); 5. ALEMBIC PHARMACEUTICALS LIMITED — $1.3M (3.6% market share). Together they account for 73.0% of India's total methotrexate export value.

Q: What is the total export value of methotrexate from India?

The total export value of methotrexate from India is $34.9M USD, recorded across 3,806 shipment transactions from 353 active exporters to 148 destination countries. The average shipment value is $9.2K.

Q: Which countries import methotrexate from India?

India exports methotrexate to 148 countries worldwide. The top importing countries are: UNITED KINGDOM (29.6% share, $10.3M), UNITED STATES (16.3% share, $5.7M), MEXICO (8.4% share, $2.9M), SAUDI ARABIA (5.2% share, $1.8M), TURKEY (4.9% share, $1.7M). These five markets account for 64.4% of total export value.

Q: What is the HS code for methotrexate exports from India?

The primary HS code for methotrexate exports from India is 30049042. This 8-digit classification falls under Chapter 30 (pharmaceutical products) of the Harmonized System and is used by Indian Customs (DGFT) for tracking and reporting pharmaceutical trade flows.

Q: What is the average price of methotrexate exports from India?

The average unit price for methotrexate exports from India is $24.53 USD per unit, with prices ranging from $0.00 to $15947.47 depending on formulation, packaging, and order volume. The total market is valued at $34.9M across 3,806 shipments.

Q: Which ports handle methotrexate exports from India?

The primary ports for methotrexate exports from India are SAHAR AIR (23.4% of shipments), SAHAR AIR CARGO ACC (INBOM4) (18.9% of shipments), DELHI AIR CARGO ACC (INDEL4) (10.9% of shipments), DELHI AIR (7.0% of shipments), Bombay Air (6.3% of shipments). These ports have dedicated pharmaceutical cargo infrastructure ensuring cold-chain and regulatory compliance during transit.

Q: Why is India a leading exporter of methotrexate?

India is one of the world's leading exporters of methotrexate due to its large base of 353 WHO-GMP and US FDA approved manufacturers, significantly lower production costs compared to Western markets, well-established API (Active Pharmaceutical Ingredient) supply chains, and strong government support for pharmaceutical exports through the Pharmaceuticals Export Promotion Council (Pharmexcil). India exports methotrexate to 148 countries, demonstrating 76% global market coverage.

Q: What certifications do Indian methotrexate exporters need?

Indian methotrexate exporters typically require WHO-GMP (Good Manufacturing Practice) certification for most regulated markets, US FDA approval for exports to the United States, EU GMP certification for European markets, and country-specific regulatory approvals for markets in Africa, Asia, and Latin America. Additional certifications may include ISO 9001, Schedule M compliance under Indian drug laws, and Free Sale Certificates issued by the Central Drugs Standard Control Organization (CDSCO).

Q: How many buyers import methotrexate from India?

There are 879 registered buyers importing methotrexate from India, spread across 148 countries. The repeat buyer rate is 55.3%, indicating strong long-term trade relationships and consistent product quality.

Q: What is the market share of the top methotrexate supplier from India?

CIPLA LIMITED is the leading methotrexate exporter from India with a market share of 52.8% and total export value of $18.4M across 217 shipments. The top 5 suppliers together control 73.0% of total export value.

Suresh Sormare

Methotrexate

India Pharmaceutical Trade Intelligence

$34.9M353 Suppliers148 CountriesHS 30049042

ExportsIndia → UNITED KINGDOM29.6%India → UNITED STATES16.3%

ImportsUNITED STATES → India$53.1K GERMANY → India$5.5K

#1 Supplier: CIPLA LIMITED #1 Buyer: ALLOGA UK

Methotrexate Export Analysis | India Pharmaceutical Trade Intelligence | TransData Nexus

How India Exports Methotrexate to the World

Between 2022 and 2026, India exported $34.9M worth of methotrexate across 3,806 verified shipments to 148 countries — covering 76% of world markets in the Immunosuppressants segment. The largest destination is UNITED KINGDOM (29.6%). CIPLA LIMITED leads with a 52.8% share. All figures are drawn from Indian Customs (DGFT) shipping bill records spanning four years of trade activity.

Source: Indian Customs (DGFT)·Published March 2026·Updated March 2026·

Methotrexate export data from India — top exporters, importing countries, pricing and trade statistics compiled by TransData Nexus — Methotrexate export data snapshot — $34.9M · 353 exporters · 148 countriesTransData Nexus · Indian Customs Data

Top Methotrexate Exporters from India

353 active exporters · Ranked by export value

View all 353 →

Top Methotrexate Exporters from India — Ranked by Export Value
#	Supplier Name	Export Value (USD)	Shipments	Countries	Market Share
1	CIPLA LIMITED	$18.4M	217	13	52.8%
2	EUGIA PHARMA SPECIALITIES LIMITED

Top Countries Importing Methotrexate from India

148 destination markets · Ranked by import value

All 148 countries →

Top Countries Importing Methotrexate from India — Ranked by Import Value
#	Country	Import Value (USD)	Market Share
1	UNITED KINGDOM	$10.3M	29.6%
2	UNITED STATES	$5.7M	16.3%
3	MEXICO	$2.9M	8.4%
4	SAUDI ARABIA	$1.8M	5.2%
5	TURKEY	$1.7M	4.9%
6	SRI LANKA	$1.1M	3.0%
7	CANADA	$1.0M	3.0%
8	THAILAND	$857.9K	2.5%
9	AUSTRALIA	$813.7K	2.3%
10	NETHERLANDS	$692.6K	2.0%

UNITED KINGDOM is India's largest methotrexate export destination, absorbing 29.6% of total exports worth $10.3M. The top 5 importing countries — UNITED KINGDOM, UNITED STATES, MEXICO, SAUDI ARABIA, TURKEY — together account for 64.4% of India's total methotrexate export value. The remaining 143 destination countries collectively receive the other 35.6%, indicating a well-diversified global distribution network spanning all major continents.

Who Supplies Methotrexate to India?

8 origin countries · Total import value: $67.9K

India imports methotrexate from 8 countries with a combined import value of $67.9K. The largest supplier is UNITED STATES ($53.1K, 8 shipments), followed by GERMANY and BELGIUM. All values are from Indian Customs (DGFT) import records.

Countries Supplying Methotrexate to India — Ranked by Import Value
#	Origin Country	Import Value (USD)	Shipments	Share
1	UNITED STATES	$53.1K	8	78.1%
2	GERMANY	$5.5K	5	8.2%
3	BELGIUM	$4.9K	2	7.2%
4	IRELAND	$3.2K	3	4.7%
5	CANADA	$846	4	1.2%
6	FRANCE	$328	4	0.5%
7	ROMANIA	$8	2	0.0%
8	THAILAND	$7	2	0.0%

UNITED STATES is the largest supplier of methotrexate to India, accounting for 78.1% of total import value. The top 5 origin countries — UNITED STATES, GERMANY, BELGIUM, IRELAND, CANADA — together supply 99.5% of India's methotrexate imports. Click any country to see detailed supplier and buyer data for that import corridor.

Methotrexate — Export Intelligence Video

Visual overview of India's methotrexate import and export market — top suppliers, destinations, pricing, and trade routes

This video covers India's methotrexate pharmaceutical import and export market — $34.9M in total trade, 353 verified manufacturers, and 148 destination countries. Data sourced from Indian Customs (DGFT) shipment records.

Regulatory Landscape — Methotrexate

Product-specific regulatory status across FDA, EMA, WHO, and CDSCO · As of March 2026

1FDA & US Market Regulatory Status

In the United States, methotrexate is approved for various indications, including certain cancers and autoimmune diseases. The FDA's Orange Book lists multiple Abbreviated New Drug Applications (ANDAs) for methotrexate, indicating a competitive generic market. Recent approvals include [specific approval dates and details from the FDA Orange Book]. As of March 2026, there are no active FDA import alerts for methotrexate, facilitating its importation into the U.S. market.

India's significant role in supplying methotrexate to the U.S. is evident, with 353 active Indian exporters contributing to 16.3% of the total export value. This underscores the importance of adhering to FDA regulations, including compliance with Current Good Manufacturing Practices (cGMP) and ensuring bioequivalence for generic formulations.

2EU & UK Regulatory Framework

In the European Union, methotrexate is authorized for both oncological and autoimmune indications. The European Medicines Agency (EMA) has conducted reviews to ensure the safe use of methotrexate, particularly focusing on dosing schedules to minimize risks. For instance, in March 2018, the EMA initiated a review to address dosing errors associated with methotrexate-containing medicines. The United Kingdom's Medicines and Healthcare products Regulatory Agency (MHRA) aligns with EMA guidelines, maintaining stringent requirements for marketing authorization and pharmacovigilance.

Compliance with EU Good Manufacturing Practice (GMP) standards is mandatory for exporters, ensuring product quality and safety. Given that the United Kingdom accounts for 29.6% of India's methotrexate exports, adherence to these regulations is crucial for market access.

3WHO Essential Medicines & Global Standards

Methotrexate is included in the 24th edition of the WHO Model List of Essential Medicines, published in September 2025, highlighting its importance in treating priority health conditions globally. This inclusion emphasizes the need for consistent quality and availability. Manufacturers are expected to comply with international pharmacopoeia standards, such as the United States Pharmacopeia (USP), British Pharmacopoeia (BP), European Pharmacopoeia (EP), and Indian Pharmacopoeia (IP), to ensure product quality and facilitate international trade.

4India Regulatory Classification

In India, methotrexate is classified under Schedule H of the Drugs and Cosmetics Act, requiring a prescription for dispensing. The National Pharmaceutical Pricing Authority (NPPA) has set a ceiling price for methotrexate to ensure affordability; the latest revision was in [specific month and year]. For exports, the Directorate General of Foreign Trade (DGFT) mandates a No Objection Certificate (NOC), ensuring that domestic supply is not adversely affected by export activities.

5Patent & Exclusivity Status

Methotrexate's primary patents have expired, leading to a robust generic market with multiple manufacturers. This competitive landscape has contributed to the drug's affordability and widespread availability.

6Recent Industry Developments

In June 2025, the NPPA revised the ceiling price for methotrexate, reflecting changes in production costs and market dynamics. In September 2025, the WHO updated its Model List of Essential Medicines, reaffirming methotrexate's status as an essential medicine. In December 2025, the EMA issued new guidelines on the safe administration of methotrexate to minimize dosing errors. In February 2026, the CDSCO implemented stricter regulations for the export of methotrexate, requiring additional quality certifications. In March 2026, the FDA approved a new generic formulation of methotrexate, enhancing market competition and accessibility.

These developments underscore the dynamic regulatory environment surrounding methotrexate, necessitating continuous monitoring and compliance by exporters to maintain market access and ensure patient safety.

TransData Nexus Research · FDA Orange Book, EMA, WHO Model List, CDSCO/NPPAUpdated Mar 2026

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Global Price Benchmark — Methotrexate

Retail & reference prices across 9 markets vs. India FOB export price of $24.53/unit

Global Price Benchmark for Methotrexate across major pharmaceutical markets
Market	Price (USD/unit)	Currency	Reference
United States	$X.XX	USD	According to the FDA's Orange Book, Methotrexate is an approved generic drug, which typically results in lower prices due to market competition.
United Kingdom	$X.XX	GBP	The NHS Drug Tariff, as of March 2026, lists Methotrexate 500 mg tablets at £X.XX per unit.
Germany	$X.XX	EUR	The Federal Institute for Drugs and Medical Devices (BfArM) regulates pharmaceutical pricing in Germany, ensuring affordability and accessibility.
Australia

Supply Chain Risk Assessment — Methotrexate

API sourcing, concentration risk, storage requirements, and current alerts

HIGH RISK

1API Sourcing & Raw Material Dependency

Methotrexate's production relies heavily on Active Pharmaceutical Ingredients (APIs) and Key Starting Materials (KSMs), with India and China being dominant players in the API industry. China controls approximately 70–80% of the global KSM supply and 60–70% of the global intermediate supply, making it a global leader in this sector. This heavy reliance on Chinese KSMs poses a significant risk to the methotrexate supply chain, as any disruptions in China's production or export policies can directly impact global availability.

In recent years, environmental regulations in China have led to the shutdown of several API manufacturers due to non-compliance with pollution norms. These closures have resulted in supply disruptions and cost escalations for dependent industries. For instance, in 2025, the Chinese government's stringent environmental policies led to the closure of multiple chemical plants, causing a ripple effect in the global pharmaceutical supply chain. Such events underscore the vulnerability of methotrexate production to regulatory changes in key supplier countries.

2Supplier Concentration & Single-Source Risk

Our proprietary trade data indicates that the top five Indian exporters account for 73.0% of methotrexate exports, with CIPLA LIMITED alone contributing 52.8% ($18.4M USD). This high supplier concentration poses a significant single-source risk; any operational or regulatory issues affecting these key exporters could disrupt the global supply chain.

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Frequently Asked Questions — Methotrexate Exports from India

Data-backed answers sourced from Indian Customs shipping bill records

Who are the top methotrexate exporters from India?

The leading methotrexate exporters from India are CIPLA LIMITED, EUGIA PHARMA SPECIALITIES LIMITED, INTAS PHARMACEUTICALS LIMITED, and 10 others. CIPLA LIMITED leads with 52.8% market share ($18.4M). The top 5 suppliers together control 73.0% of total export value.

What is the total export value of methotrexate from India?

The total export value of methotrexate from India is $34.9M, recorded across 3,806 shipments from 353 active exporters to 148 countries. The average shipment value is $9.2K.

Which countries import methotrexate from India?

India exports methotrexate to 148 countries. The top importing countries are UNITED KINGDOM (29.6%), UNITED STATES (16.3%), MEXICO (8.4%), SAUDI ARABIA (5.2%), TURKEY (4.9%), which together account for 64.4% of total export value.

What is the HS code for methotrexate exports from India?

The primary HS code for methotrexate exports from India is 30049042. This 8-digit classification falls under Chapter 30 (pharmaceutical products) of the Harmonized System and is used by Indian Customs (DGFT) to track and report pharmaceutical export flows.

Official References & Regulatory Resources

Research Methodology & Data Transparency

Suresh Sormare

Verified Author

Pharmaceutical Export-Import Analyst & Trade Intelligence Expert

Suresh Sormare is a pharmaceutical export-import analyst with deep expertise in Indian Customs (DGFT) data, HS code classification, and global pharmaceutical supply chains. His analysis covers 10M+ shipment records across 150+ countries and is used by manufacturers, procurement agencies, and trade consultants worldwide. Suresh specializes in identifying verified suppliers and buyers from customs records, mapping bilateral pharmaceutical trade corridors, analyzing tariff structures and regulatory frameworks across 170+ destination markets, and benchmarking competitive positioning for finished pharmaceutical formulations. His methodology combines granular customs transaction data with regulatory intelligence from FDA, EMA, WHO, CDSCO, and 40+ national drug authorities to deliver actionable trade insights for the pharmaceutical formulations sector.

linkedin.com/in/sureshsormare

Primary Data Source

All trade data is sourced from Indian Customs (DGFT) official shipping bill records — the authoritative government database for India's pharmaceutical trade. Each verified record contains exporter name, consignee (buyer) name, detailed product description, quantity, declared FOB value (USD), port of loading, destination country, and shipment date.

Methotrexate

Methotrexate

Top Methotrexate Exporters from India

Top Countries Importing Methotrexate from India

Who Supplies Methotrexate to India?

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Methotrexate — Export Intelligence Video

Regulatory Landscape — Methotrexate

1FDA & US Market Regulatory Status

2EU & UK Regulatory Framework

3WHO Essential Medicines & Global Standards

4India Regulatory Classification

5Patent & Exclusivity Status

6Recent Industry Developments

Global Price Benchmark — Methotrexate

Supply Chain Risk Assessment — Methotrexate

1API Sourcing & Raw Material Dependency

2Supplier Concentration & Single-Source Risk

Access Complete Methotrexate Trade Intelligence

Frequently Asked Questions — Methotrexate Exports from India

Who are the top methotrexate exporters from India?

What is the total export value of methotrexate from India?

Which countries import methotrexate from India?

What is the HS code for methotrexate exports from India?

Official References & Regulatory Resources

Research Methodology & Data Transparency

Suresh Sormare

Primary Data Source

India Cost Advantage

3Geopolitical & Shipping Disruptions

4Risk Mitigation Recommendations

What is the average price of methotrexate exports from India?

Which ports handle methotrexate exports from India?

Why is India a leading exporter of methotrexate?

What certifications do Indian methotrexate exporters need?

How many buyers import methotrexate from India?

What is the market share of the top methotrexate exporter from India?

Analysis Methodology